反应详情

To esomeprazole (20 gm) was added acetone (100 ml) and pyrrolidine (7 gm) at room temperature. The reaction mixture was stirred for 1 hour at room temperature and the solid was separated. The separated solid was cooled to 10 to 15° C. and maintained for 1 hour at 10 to 15° C. The solid obtained was collected by filtration, washed with chilled acetone and then dried at 40 to 45° C. under vacuum to obtain 16 gm of esomeprazole pyrrolidine salt.

1. customthe solid was separated
2. temperatureThe separated solid was cooled to 10 to 15° C.
3. temperaturemaintained for 1 hour at 10 to 15° C
4. customThe solid obtained
5. filtrationwas collected by filtration
6. washwashed with chilled acetone
7. customdried at 40 to 45° C. under vacuum