Hydrochloric Acid → HCID 16192951, compound

HRID 404626Notes

Reaction equation

HRID 404626 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([CH:8]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:9]([O:11]CC)=[O:10])[CH2:4][CH2:3]1.[ClH:20]>O1CCOCC1>[ClH:20].[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([CH:8]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:9]([OH:11])=[O:10])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86688887HCID 86688887, compound

Product 1

HCID 16192951HCID 16192951, compoundYield 96.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

Ethyl 2-(4-methylpiperidin-1-yl)-2-phenylacetate (225 mg, 0.86 mmol) and 37% aq HCl (0.52 ml, 17.2 mmol) were dissolved in Dioxane (7 ml) and heated under microwave irradiation into a sealed vial at 100° C. for 8 hours. The solvents were evaporated, the residue was suspended in EtOAc and evaporated. The residue was suspended in EtOAc/Et2O (1/1), sonicated and filtered under suction to obtain 2-(4-methylpiperidin-1-yl)-2-phenylacetic acid hydrochloride (223 mg, 96% yield) as a white solid

Workup

  1. customThe solvents were evaporated
  2. customevaporated
  3. customsonicated
  4. filtrationfiltered under suction

Sources & evidence

ORD record
ord-32d727e300be410dbca8270556c9a1b7
Source dataset
uspto-grants-2014_06
Patent number
US08748613B2

Reaction notes

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