Diisopropylethylamine → HCID 53530378, compound

HRID 404645Notes

Reaction equation

HRID 404645 reaction equation
Br[CH:2]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:3]([O:5][CH2:6][CH3:7])=[O:4].CCN(C(C)C)C(C)C.[N:23]1([C:29](=[O:31])[CH3:30])[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>C(#N)C>[C:29]([N:23]1[CH2:28][CH2:27][N:26]([CH:2]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:3]([O:5][CH2:6][CH3:7])=[O:4])[CH2:25][CH2:24]1)(=[O:31])[CH3:30]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 837951-AcetylpiperazineHCID 97780Ethyl bromophenylacetate

Product 1

HCID 53530378HCID 53530378, compoundYield 95.5%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Ethyl 2-bromo-2-phenylacetate (0.22 ml, 1.23 mmol) was dissolved in acetonitrile (4 ml) and DIPEA (0.28 ml, 1.60 mmol) and 1-(piperazin-1-yl)ethanone (0.21 g, 1.60 mmol) were sequentially added. The reaction was stirred at room temperature overnight. The solvent was evaporated and the residue was purified by flash chromatography (DCM/Acetone=9/1) to obtain ethyl 2-(4-acetylpiperazin-1-yl)-2-phenylacetate (341 mg, 95% yield) as a pale yellow oil.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was purified by flash chromatography (DCM/Acetone=9/1)

Sources & evidence

ORD record
ord-d82401af354b4eada2a4d36004d12468
Source dataset
uspto-grants-2014_06
Patent number
US08748613B2

Reaction notes

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