反应详情

温度

100 °C

Methyl 2-(3-fluorophenyl)-2-(piperidin-1-yl)acetate (224 mg, 0.89 mmol) and 37% HCl (813 μl, 26.7 mmol) were dissolved in dioxane (3 ml) and stirred under microwave irradiation at 100° C. for 6 hours. The solvents were evaporated and the residue was triturated with Et2O and sonicated. The solid was collected by suction filtration, washed with Et2O and dried under vacuum overnight to collect 2-(3-fluorophenyl)-2-(piperidin-1-yl)acetic acid hydrochloride (230 mg, 94% yield).

1. customThe solvents were evaporated
2. customthe residue was triturated with Et2O
3. customsonicated
4. filtrationThe solid was collected by suction filtration
5. washwashed with Et2O
6. customdried under vacuum overnight