Hydrochloric Acid → HCID 86688935, compound

HRID 404673Notes

Reaction equation

HRID 404673 reaction equation
[N:1]1([CH:7]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)[C:8]([O:10]C)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:19]>O1CCOCC1>[ClH:19].[N:1]1([CH:7]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)[C:8]([OH:10])=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 25233387HCID 25233387, compound

Product 1

HCID 86688935HCID 86688935, compoundYield 81.6%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of methyl 2-(piperidin-1-yl)-2-p-tolylacetate (273 mg, 1.10 mmol) in dioxane (2 ml), was added 37% HCl (3.35 ml, 110 mmol). The reaction was heated under microwave irradiation at 100° C. for 4 hours. The solvents were evaporated and the residue was triturated with Et2O to collect 2-(piperidin-1-yl)-2-p-tolylacetic acid hydrochloride (242 mg, 81% yield) as a white solid.

Workup

  1. customThe solvents were evaporated
  2. customthe residue was triturated with Et2O

Sources & evidence

ORD record
ord-24019b24a62c460caa93704f34673916
Source dataset
uspto-grants-2014_06
Patent number
US08748613B2

Reaction notes

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