反应详情

2-Bromo-2-(4-chlorophenyl)acetic acid (300 mg, 1.20 mmol), piperidine (125 μl, 1.26 mmol) and TEA (503 μl, 3.61 mmol) were dissolved in acetonitrile (6 ml). The resulting reaction was stirred at room temperature for 48 hours. Acetonitrile was evaporated, the residue was triturated with acetonitrile/petroleum ether (9/1) and filtered by suction filtration to collect 2-(4-chlorophenyl)-2-(piperidin-1-yl)acetic acid (190 mg, 62.3% yield) as a white solid.

1. customThe resulting reaction
2. customAcetonitrile was evaporated
3. customthe residue was triturated with acetonitrile/petroleum ether (9/1)
4. filtrationfiltered by suction filtration