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HRID404685

反应详情

EQUATION

反应方程式

HRID 404685 的结构方程式

REACTANTS

反应物

3
结构：CCOCC
HCID3283

Diethyl Ether

C4H10O

结构：O=C(CCl)c1cccs1
HCID2757925

2-Chloro-1-(thiophen-2-yl)ethan-1-one

C6H5ClOS

结构：O=C(O[C@H]1CN2CCC1CC2)C(c1ccc(F)cc1)N1CCCCC1
HCID86688942

未命名化合物

PRODUCTS

生成物

1
结构：O=C(C[N+]12CCC(CC1)[C@@H](OC(=O)C(c1ccc(F)cc1)N1CCCCC1)C2)c1cccs1.[Cl-]
HCID86688945

未命名化合物

收率 26.7%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

2-Chloro-1-(thiophen-2-yl)ethanone (30.6 mg, 0.19 mmol) was added to a solution of (R)-quinuclidin-3-yl 2-(4-fluorophenyl)-2-(piperidin-1-yl)acetate (60 mg, 0.17 mmol) in EtOAc (3 ml). The reaction was stirred at room temperature for 16 hours. Et2O was added the precipitate was collected by filtration and purified by flash chromatography (DCM/MeOH/NH4OH=97/3/0.3) to obtain (3R)-3-(2-(4-fluorophenyl)-2-(piperidin-1-yl)acetoxy)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane chloride (23 mg, 26.2% yield) as a white solid.

WORKUP

后处理

  1. filtrationwas collected by filtration
  2. custompurified by flash chromatography (DCM/MeOH/NH4OH=97/3/0.3)