反应详情

温度

140 °C

2,6-Dimethyl-pyridin-3-ol (3.0 g, 24.35 mmol) and cesium carbonate (15.87 g, 48.71 mmol) were added to a solution of 3,4-difluoronitrobenzene (3.87 g, 24.35 mmol) in DMF (30 ml). The mixture was heated at 140° C. for 2 hours. After cooling to room temperature it was filtered through diatomaceous earth and the solvent evaporated in vacuo. The crude product was purified by column chromatography (silica gel; 2% methanol/DCM as eluent) to yield intermediate D14 (5.88 g, 92%).

1. temperatureAfter cooling to room temperature it
2. filtrationwas filtered through diatomaceous earth
3. customthe solvent evaporated in vacuo
4. customThe crude product was purified by column chromatography (silica gel; 2% methanol/DCM as eluent)
5. customto yield intermediate D14 (5.88 g, 92%)