反应详情

温度

100 °C

To a solution of 42.8 g (173.5 mmol) of 6-Bromo-1-chloro-isoquinoline (5) in 700 ml of acetic acid were added 133.6 g (1.74 mol) ammonium acetate. After stirring at 100° C. for 3 h, the solution was cooled to room temperature and the solvent was removed i. vac. to a small volume. The residue was poured on water and the suspension was stirred for some minutes. The precipitate was isolated by filtration and dried, to yield 28.2 g of the title compound. Rt=1.30 min (Method B). Detected mass: 224.0 (M+H+).

1. temperaturethe solution was cooled to room temperature
2. customthe solvent was removed i
3. additionThe residue was poured on water
4. stirringthe suspension was stirred for some minutes
5. customThe precipitate was isolated by filtration
6. customdried