6-Bromo-2-[(4-methoxyphenyl)methyl]-1(2H)-isoquinolinone → 6-Bromo-7-chloro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one

HRID 404727Notes

Reaction equation

HRID 404727 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[C:8](=[O:13])[NH:7][CH:6]=[CH:5]2.BrC1C=C2C(=CC=1)C(=O)N([CH2:26][C:27]1[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=1)C=C2>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[C:8](=[O:13])[N:7]([CH2:26][C:27]1[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=1)[CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 575517716-Bromo-2-[(4-methoxyphenyl)methyl]-1(2H)-isoquinolinone2×HCID 592262786-Bromo-7-chloro-1,2-dihydroisoquinolin-1-one

Product 1

HCID 592262596-Bromo-7-chloro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one

Procedure

Starting from 6-Bromo-7-chloro-2H-isoquinolin-1-one (12), the title compound was prepared by the method described for 6-Bromo-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one (compound 13). Rt=2.12 min (Method B). Detected mass: 378.1/380.1 (M+H+).

Sources & evidence

ORD record
ord-251e16e724134b19a8a1c48725ac46ed
Source dataset
uspto-grants-2014_06
Patent number
US08748614B2

Reaction notes

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