反应详情

To a solution of 3.93 g (17.5 mmol) 6-Bromo-2H-isoquinolin-1-one (6) in 150 ml Toluene were added 12.13 g (44.0 mmol) silver carbonate and 3.60 g (21.1 mmol) of benzyl bromide. The reaction mixture was refluxed for 1.5 h and then cooled to room temperature. The solution was filtered. The filtrate was washed with water and the aqueous phase extracted with ethyl acetate. The combined organic layers were dried over magnesium sulfate and evaporated. Final purification was achieved by preparative HPLC. Rt=2.47 min (Method B). Detected mass: 314.1/316.5 (M+H+).

1. temperatureThe reaction mixture was refluxed for 1.5 h
2. filtrationThe solution was filtered
3. washThe filtrate was washed with water
4. extractionthe aqueous phase extracted with ethyl acetate
5. dry with materialThe combined organic layers were dried over magnesium sulfate
6. customevaporated
7. customFinal purification