6-Bromo-7-chloroisoquinoline → 6-Bromo-7-chloro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one

HRID 404733Notes

Reaction equation

HRID 404733 reaction equation
BrC1C=C2C(=CC=1[Cl:12])C=NC=C2.[Br:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][CH:23]=1)[C:20](=[O:24])[N:19]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=1)[CH:18]=[CH:17]2>>[Br:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][C:23]=1[Cl:12])[C:20](=[O:24])[N:19]([CH2:25][C:26]1[CH:27]=[CH:28][C:29]([O:32][CH3:33])=[CH:30][CH:31]=1)[CH:18]=[CH:17]2

Participants

3

Reactant 2

HCID 534186156-Bromo-7-chloroisoquinolineHCID 575517716-Bromo-2-[(4-methoxyphenyl)methyl]-1(2H)-isoquinolinone

Product 1

HCID 592262596-Bromo-7-chloro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one

Procedure

Starting from 6-Bromo-7-chloro-isoquinoline (263), the title compound was prepared by the method described for 6-Bromo-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one (13). Rt=1.66 min (Method C). Detected mass: 318.3 (M+H+).

Sources & evidence

ORD record
ord-6fa36d25e0454c5bb92cd593d6d543f1
Source dataset
uspto-grants-2014_06
Patent number
US08748614B2

Reaction notes

Loading…