Hydrochloric Acid → 7-Chloro-6-(piperidin-3-ylmethylsulfanyl)-isoquinoline hydrochloride

HRID 404747Notes

Reaction equation

HRID 404747 reaction equation
BrC1C=C2C(=CC=1[Cl:12])C=NC=C2.[Cl:13][C:14]1[CH:23]=[C:22]2[C:17]([CH:18]=[CH:19][N:20]=[CH:21]2)=[CH:16][C:15]=1[S:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][NH:28][CH2:27]1.C(OC(N1CCCC(CBr)C1)=O)(C)(C)C.Cl>>[ClH:12].[Cl:13][C:14]1[CH:23]=[C:22]2[C:17]([CH:18]=[CH:19][N:20]=[CH:21]2)=[CH:16][C:15]=1[S:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][NH:28][CH2:27]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 534186156-Bromo-7-chloroisoquinolineHCID 685924673-Bromomethyl-piperidine-1-carboxylic acid tert-butyl ester 7-Chloro-6-(piperidin-3-ylmethylsulfanyl)-isoquinoline

Product 1

HCID 685930427-Chloro-6-(piperidin-3-ylmethylsulfanyl)-isoquinoline hydrochloride

Procedure

Starting from 6-Fluoro-7-chloroisoquinoline (263) and 3-Bromomethyl-piperidine-1-carboxylic acid tert-butyl ester 7-Chloro-6-(piperidin-3-ylmethylsulfanyl)-isoquinoline could be obtained according to the procedures described for 272, 267, 268 as the hydrochloride. Rt=0.75 min (Method B). Detected mass: 293.1/295.1 (M+H+).

Workup

  1. customcould be obtained

Sources & evidence

ORD record
ord-97f48f2a7c024a7a8788cfee77df0c7e
Source dataset
uspto-grants-2014_06
Patent number
US08748614B2

Reaction notes

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