HCID 59290595, compound → HCID 59290640, compound

HRID 404754Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([S:14]([C:17]2[CH:18]=[C:19]3[C:24](=[CH:25][C:26]=2[Cl:27])[C:23](=[O:28])[N:22](CC2C=CC(OC)=CC=2)[CH:21]=[CH:20]3)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C>C(O)(C(F)(F)F)=O>[Cl:27][C:26]1[CH:25]=[C:24]2[C:19]([CH:20]=[CH:21][NH:22][C:23]2=[O:28])=[CH:18][C:17]=1[S:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)(=[O:15])=[O:16]

Participants

Conditions

Temperature: 150 °C

Procedure

190 mg 4-[7-Chloro-2-(4-methoxy-benzyl)-1-oxo-1,2-dihydro-isoquinoline-6-sulfonyl]-piperidine-1-carboxylic acid tert-butyl ester (287) were dissolved in 2 ml of TFA and heated in a microwave at 150° C. for 50 min in total. After evaporation the mixture was dissolved in 1 N HCl and extracted with dichloromethane and lyophilized. 58 mg of 7-Chloro-6-(piperidine-4-sulfonyl)-2H-isoquinolin-1-one could be obtained as the hydrochloride. Rt=0.81 min (Method B). Detected mass: 327.1/329.1 (M+H+).

Workup

customAfter evaporation the mixture
dissolutionwas dissolved in 1 N HCl
extractionextracted with dichloromethane

Sources & evidence

ORD record: ord-4ac8efeb2cbf49d684c76d7ce93f7879
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08748614B2

Reaction notes

Loading…