反应详情

温度

20 °C

To a suspension of 23.8 g (0.42 mol) of potassium hydroxide in 220 ml of N,N-dimethylformamide at 10° C. are added 40.0 g of ethyl N-hydroxyethaneimidoate (0.39 mol) (compound VI: R3═C2H5; R4═CH3). A solution of 55.6 g of 4-chloronitrobenzene (0.35 mol) (compound V: Hal=Cl) (55.6 g) in N,N-dimethylformamide is then added slowly, at 10° C. The mixture is stirred for 24 hours at 20° C. and 1 L of water is then added. The precipitate is filtered off and the solid is washed with water and oven-dried at 30° C. under vacuum to constant weight.

1. filtrationThe precipitate is filtered off
2. washthe solid is washed with water
3. customoven-dried at 30° C. under vacuum to constant weight