反应详情

To a solution of Example 17B (1.42 g, 5.56 mmol) in pyridine (10 mL) was added hydroxylamine hydrochloride (3.30 g, 47.5 mmol). The mixture was heated to reflux with a heat gun. After cooling, the mixture was poured into 10% HCl. The precipitates were collected and washed with 10% HCl followed by water, and then dried under vacuum at 50° C. overnight to give the desired product as a white solid (1.48 g, 98%).

1. temperatureThe mixture was heated
2. temperatureto reflux with a heat gun
3. temperatureAfter cooling
4. customThe precipitates were collected
5. washwashed with 10% HCl
6. customdried under vacuum at 50° C. overnight