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Acetic Anhydride → N-((1S)-1-(4-Bromophenyl)ethyl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | (alphaS)-4-Bromo-alpha-methylbenzenemethanamine | HCID 852999 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-((1S)-1-(4-Bromophenyl)ethyl)acetamide | HCID 793484 | — |
反応手順
23.6 mL (250 mmol) acetic anhydride are added to 50.0 g (250 mmol) (S)-1-(4-bromophenyl)-ethylamine in 200 mL DCM while keeping the reaction temperature below 30° C. Stirring is continued for 12 h at rt. After that time, saturated NaHCO3-solution is added. The organic layer is separated, washed with water, dried over magnesium sulphate and the solvent is removed by evaporation.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08530461B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-f96979fe72f74084b61a860b344e7a4f |
| 出典メモ | uspto-grants-2013_09 |