Ammonium Hydroxide → HCID 86605522, compound

HRID 404999Notes

Reaction equation

HRID 404999 reaction equation
[OH-].[NH4+:2].[N:3]([CH2:6][CH2:7][CH2:8][S:9](Cl)(=[O:11])=[O:10])=[N+:4]=[N-:5]>C(O)C>[N:3]([CH2:6][CH2:7][CH2:8][S:9]([NH2:2])(=[O:11])=[O:10])=[N+:4]=[N-:5]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 538209503-Azidopropane-1-sulfonyl chloride

Product 1

HCID 86605522HCID 86605522, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ammonium hydroxide (28%) (10 mL) was added to a solution of 3-azido-1-propanesulfonyl chloride (˜2.29 g, 12.53 mmol; obtained in step 2) in ethanol (10 mL). The reaction mixture was stirred at room temperature for 3 h then concentrated. The residual material was passed through a short silica gel column using hexanes:ethyl acetate as eluent to isolate 3-azido-1-propanesulfonamide (1.5 g, 86%).

Workup

  1. concentrationthen concentrated

Sources & evidence

ORD record
ord-44f2ef1886bf4c5a910a7febca11a14d
Source dataset
uspto-grants-2014_06
Patent number
US08748656B2

Reaction notes

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