Hydrogen Bromide → (S)-methyl 2-amino-4,4-difluoro-5-phenylpentanoate hydrobromide

HRID 405032Notes

Reaction equation

HRID 405032 reaction equation
C(OC([NH:11][C@@H:12]([CH2:17][C:18]([F:27])([F:26])[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:13]([O:15][CH3:16])=[O:14])=O)C1C=CC=CC=1.[BrH:28]>>[BrH:28].[NH2:11][C@@H:12]([CH2:17][C:18]([F:26])([F:27])[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:13]([O:15][CH3:16])=[O:14]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 57535357Methyl (S)-2-benzyloxycarbonylamino-4,4-difluoro-5-phenylpentanoate

Product 1

HCID 66939992(S)-methyl 2-amino-4,4-difluoro-5-phenylpentanoate hydrobromide

Procedure

A mixture of (S)-methyl 2-(benzyloxycarbonylamino)-4,4-difluoro-5-phenylpentanoate (188 mg, 0.5 mmol) and hydrogen bromide (2 mL) was stirred at RT for two hr, after which the solvent was removed to give the title (S)-methyl 2-amino-4,4-difluoro-5-phenylpentanoate hydrobromide.

Workup

  1. customafter which the solvent was removed

Sources & evidence

ORD record
ord-d6bdb3309f6e49a1ba255ed62d5cfb95
Source dataset
uspto-grants-2014_06
Patent number
US08748649B2

Reaction notes

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