4-Oxazolecarboxylic acid, 2-(acetylamino)-, ethyl ester → 2-Acetamidooxazole-4-carboxylic acid

HRID 40504Notes

Reaction equation

HRID 40504 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][C:12](=[O:14])[CH3:13])[O:9][CH:10]=1)=[O:5])C>C(O)C>[C:12]([NH:11][C:8]1[O:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=1)(=[O:14])[CH3:13]

Participants

3

Reactant 1

HCID 2153734-Oxazolecarboxylic acid, 2-(acetylamino)-, ethyl ester

Product 1

HCID 840118932-Acetamidooxazole-4-carboxylic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.3 g (6.60 mmol) 2-Acetylamino-oxazole-4-carboxylic acid ethyl ester is added to 33 mL ethanol. 0.55 g (13.2 mmol) LiOH monohydrate is added and the mixture is stirred for 12 h at rt. The mixture is concentrated in vacuo, acidified by means of aq. HCl solution and the precipitate is collected and washed with cold water to yield the desired product.

Workup

  1. concentrationThe mixture is concentrated in vacuo
  2. customthe precipitate is collected
  3. washwashed with cold water

Sources & evidence

ORD record
ord-e363e39bc3a3467ba41fe9eef87d8f31
Source dataset
uspto-grants-2013_09
Patent number
US08530461B2

Reaction notes

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