4-Oxazolecarboxylic acid, 2-(acetylamino)-, ethyl ester → 2-Acetamidooxazole-4-carboxylic acid

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Reaction Steps

1.3 g (6.60 mmol) 2-Acetylamino-oxazole-4-carboxylic acid ethyl ester is added to 33 mL ethanol. 0.55 g (13.2 mmol) LiOH monohydrate is added and the mixture is stirred for 12 h at rt. The mixture is concentrated in vacuo, acidified by means of aq. HCl solution and the precipitate is collected and washed with cold water to yield the desired product.

Provenance & Evidence