反应详情

温度

80 °C

A mixture of 2.6 g (10.4 mmol) 3-methanesulfonyloxy-azetidine-1-carboxylic acid tert-butyl ester, 1.7 g (10.4 mmol) 4-cyclopropylmethoxy-phenol and 6.7 g (20.7 mmol) Cs2CO3 in 60 mL DMF is stirred for 12 h at 80° C. Water is added and the mixture is extracted with ethyl acetate (2×). The combined organic layers are washed with NaHCO3 solution and are dried over MgSO4. The solvent is evaporated and the residue is purified by column chromatography (silica gel; PE/ethyl acetate; gradient 9:1→8:2) to yield the desired product.

1. extractionthe mixture is extracted with ethyl acetate (2×)
2. washThe combined organic layers are washed with NaHCO3 solution
3. dry with materialare dried over MgSO4
4. customThe solvent is evaporated
5. customthe residue is purified by column chromatography (silica gel; PE/ethyl acetate; gradient 9:1→8:2)