Sodium Hydroxide → HCID 71059979, compound

HRID 405178Notes

Reaction equation

HRID 405178 reaction equation
[OH-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([C:11]2[CH:16]=[CH:15][C:14]([NH:17][CH2:18][C:19]3[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[CH:21][C:20]=3[C:27]3[CH:28]=[CH:29][C:30]([C:33]([NH:35][CH2:36][CH2:37][C:38]([O:40]CC)=[O:39])=[O:34])=[N:31][CH:32]=3)=[CH:13][CH:12]=2)[CH:7]=[CH:8][C:9]=1[Cl:10]>C1COCC1>[Cl:3][C:4]1[CH:5]=[C:6]([C:11]2[CH:16]=[CH:15][C:14]([NH:17][CH2:18][C:19]3[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[CH:21][C:20]=3[C:27]3[CH:28]=[CH:29][C:30]([C:33]([NH:35][CH2:36][CH2:37][C:38]([OH:40])=[O:39])=[O:34])=[N:31][CH:32]=3)=[CH:13][CH:12]=2)[CH:7]=[CH:8][C:9]=1[Cl:10]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 71060030HCID 71060030, compound

Product 1

HCID 71059979HCID 71059979, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A 3M aqueous solution of NaOH (0.20 mL, 0.60 mmol) was added to a THF solution (3 mL) of ethyl 3-(5-(2-(((3′,4′-dichloro-[1,1′-biphenyl]-4-yl)amino)methyl)-4-methoxyphenyl)picolinamido)propanoate (116 mg, 0.20 mmol) and the resulting mixture was stirred at room temperature. After 16 h the resulting mixture was concentrated in vacuo, suspended in water, and acidified with 2 M HCl. The resulting precipitate was filtered off and dried in vacuo to yield the title compound.

Workup

  1. concentrationAfter 16 h the resulting mixture was concentrated in vacuo
  2. filtrationThe resulting precipitate was filtered off
  3. customdried in vacuo

Sources & evidence

ORD record
ord-41623f3338ea43a3a723e424476d47d7
Source dataset
uspto-grants-2014_06
Patent number
US08748624B2

Reaction notes

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