4'-Chloro-2'-methyl-[1,1'-biphenyl]-4-amine → 3-(5-(4-Chloro-2-(((2,4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoic acid

HRID 405199Notes

Reaction equation

HRID 405199 reaction equation
Cl[C:2]1[C:3]([CH2:26][NH:27][C:28]2[CH:33]=[CH:32][C:31]([C:34]3[CH:39]=[CH:38][C:37]([Cl:40])=[CH:36][CH:35]=3)=[C:30]([Cl:41])[CH:29]=2)=[C:4]([C:12]2[CH:13]=[CH:14][C:15]([C:18]([NH:20][CH2:21][CH2:22][C:23]([OH:25])=[O:24])=[O:19])=[N:16][CH:17]=2)[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[Cl:42]C1C=CC(C2C=CC(N)=CC=2)=C(C)C=1>>[Cl:42][C:7]1[C:6]([C:8]([F:9])([F:11])[F:10])=[CH:5][C:4]([C:12]2[CH:13]=[CH:14][C:15]([C:18]([NH:20][CH2:21][CH2:22][C:23]([OH:25])=[O:24])=[O:19])=[N:16][CH:17]=2)=[C:3]([CH2:26][NH:27][C:28]2[CH:33]=[CH:32][C:31]([C:34]3[CH:39]=[CH:38][C:37]([Cl:40])=[CH:36][CH:35]=3)=[C:30]([Cl:41])[CH:29]=2)[CH:2]=1

Participants

3

Reactant 2

HCID 672116234'-Chloro-2'-methyl-[1,1'-biphenyl]-4-amineHCID 866742713-(5-(3-Chloro-2-(((2,4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoic acid

Product 1

HCID 866742703-(5-(4-Chloro-2-(((2,4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoic acid

Procedure

The title compound was prepared as described in Example 77 substituting 2,4′-dichloro-[1,1′-biphenyl]-4-amine (see Example 74) for 4′-chloro-2′-methyl-[1,1′-biphenyl]-4-amine.

Sources & evidence

ORD record
ord-dfee4fe51cfa4e36ad5738a458845e1c
Source dataset
uspto-grants-2014_06
Patent number
US08748624B2

Reaction notes

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