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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 405199Generated: October 29, 2026

4'-Chloro-2'-methyl-[1,1'-biphenyl]-4-amine → 3-(5-(4-Chloro-2-(((2,4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoic acid

https://huagongshe.com/reaction/405199

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4'-Chloro-2'-methyl-[1,1'-biphenyl]-4-amineHCID 67211623—
Reactant3-(5-(3-Chloro-2-(((2,4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoic acidHCID 86674271—
Product3-(5-(4-Chloro-2-(((2,4'-dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-5-(trifluoromethyl)phenyl)picolinamido)propanoic acidHCID 86674270—

Reaction Steps

The title compound was prepared as described in Example 77 substituting 2,4′-dichloro-[1,1′-biphenyl]-4-amine (see Example 74) for 4′-chloro-2′-methyl-[1,1′-biphenyl]-4-amine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08748624B2
Source datasetuspto-grants-2014_06
ORD IDord-dfee4fe51cfa4e36ad5738a458845e1c
Source noteuspto-grants-2014_06