反应详情

A 3M aqueous solution of NaOH (0.28 mL, 0.84 mmol) was added to a THF solution (0.9 mL) of ethyl 3-(5-(2-(((2-chloro-4′-fluoro-3′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)amino)methyl)-4,5-difluorophenyl)picolinamido)propanoate (100 mg, 0.17 mmol) and the resulting mixture was stirred at room temperature. After 16 h the resulting mixture was concentrated and purified via HPLC to yield the title compound.

1. concentrationAfter 16 h the resulting mixture was concentrated
2. custompurified via HPLC