참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Ethyl 3-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamido)propanoate | HCID 71059832 | — |
| 반응물 | 2-bromo-N-(4'-chloro-[1,1'-biphenyl]-4-yl)-4-methylbenzamide | HCID 71060083 | — |
| 촉매 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | HCID 71060074 | HCID 71060074 | — |
반응 단계
2-bromo-N-(4′-chloro-[1,1′-biphenyl]-4-yl)-4-methylbenzamide (50 mg, 0.13 mmol), ethyl 3-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamido)propanoate (68 g, 0.16 mmol), Pd(dppf)Cl2 (9 mg, 0.01 mmol), and 2M aqueous K2CO3 (0.13 mL g, 0.25 mmol) were dissolved in 1,4-dioxane (2 mL) and the resulting mixture was heated to 85° C. After 16 h the resulting mixture was cooled to room temperature and purified directly via column chromatography to yield the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08748624B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_06 |
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| ORD ID | ord-3d9e502c645b4889a19aaf553fe4cc55 |
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| 출처 메모 | uspto-grants-2014_06 |
|---|
