Beta-Alanine → HCID 62958519, compound

Participants

Reaction Steps

Neat Et3N (5.2 mL, 37.5 mmol) was added to a DCM mixture (50 mL) of 5-bromopicolinic acid (5.1 g, 25.0 mmol), beta-alanine mether ester hydrochloride (4.2 g, 30.0 mmol), and EDCI (5.8 g, 30 mmol) and the resulting mixture was stirred at room temperature. After 24 h the resulting mixture was poured into CH2Cl2/H2O (50 mL/50 mL). The aqueous layer was extracted with CH2Cl2 (50 mL). The combined organic layers were dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.

Provenance & Evidence