反应详情

Neat Et3N (5.2 mL, 37.5 mmol) was added to a DCM mixture (50 mL) of 5-bromopicolinic acid (5.1 g, 25.0 mmol), beta-alanine mether ester hydrochloride (4.2 g, 30.0 mmol), and EDCI (5.8 g, 30 mmol) and the resulting mixture was stirred at room temperature. After 24 h the resulting mixture was poured into CH2Cl2/H2O (50 mL/50 mL). The aqueous layer was extracted with CH2Cl2 (50 mL). The combined organic layers were dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.

1. extractionThe aqueous layer was extracted with CH2Cl2 (50 mL)
2. dry with materialThe combined organic layers were dried (Na2SO4)
3. concentrationconcentrated
4. custompurified via column chromatography