反应详情

温度

90 °C

4-bromo-3-chloroaniline (2.1 g, 10.2 mmol), (4-(trifluoromethyl)phenyl)boronic acid (2.7 g, 14.2 mmol), Pd(dppf)Cl2 (744 mg, 1.0 mmol), 2M aqueous Na2CO3 (15.3 mL, 30.5 mmol) were dissolved in 1,4-dioxane (30 mL) and the resulting mixture was heated to 90° C. After 16 h the resulting mixture was cooled to room temperature, was diluted with EtOAc, washed with water and brine. The organic layer was dried (Na2SO4), concentrated and diethyl ether was added. The resulting precipitate was filtered and dried in vacuo to yield the title compound.

1. temperatureAfter 16 h the resulting mixture was cooled to room temperature
2. washwashed with water and brine
3. dry with materialThe organic layer was dried (Na2SO4)
4. concentrationconcentrated
5. additiondiethyl ether was added
6. filtrationThe resulting precipitate was filtered
7. customdried in vacuo