4-Chlorophenylboronic acid → 2,4',6-Trichloro-[1,1'-biphenyl]-4-amine

HRID 405248Notes

Reaction equation

HRID 405248 reaction equation
Br[C:2]1[C:8]([Cl:9])=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[Cl:10].[Cl:11][C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1.BrC1C=CC(N)=CC=1Cl.FC(F)(F)C1C=CC(B(O)O)=CC=1>>[Cl:10][C:3]1[CH:4]=[C:5]([NH2:6])[CH:7]=[C:8]([Cl:9])[C:2]=1[C:15]1[CH:16]=[CH:17][C:12]([Cl:11])=[CH:13][CH:14]=1

Participants

5

Reactant 4

HCID 742994-Chlorophenylboronic acidHCID 888884-Bromo-3-chloroanilineHCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 137497104-Bromo-3,5-dichloroaniline

Product 1

HCID 681310252,4',6-Trichloro-[1,1'-biphenyl]-4-amine

Procedure

The title compound was prepared as described in Example 159 substituting 4-bromo-3,5-dichloroaniline and (4-chlorophenyl)boronic acid for 4-bromo-3-chloroaniline and (4-(trifluoromethyl)phenyl)boronic acid, respectively.

Sources & evidence

ORD record
ord-be48c29f54e94c7996f52d7909cc6a32
Source dataset
uspto-grants-2014_06
Patent number
US08748624B2

Reaction notes

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