HRID405258

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID19878910

未命名化合物

PRODUCTS

生成物

结构：O=C(O)CCNC(=O)c1ccc(-c2cc(C(F)(F)F)cc(O)c2CNc2ccc(-c3ccc(Cl)cc3)c(Cl)c2)cn1

HCID71059918

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as described in Example 159 substituting ethyl 3-(5-(2-formyl-3-hydroxy-5-(trifluoromethyl)phenyl)picolinamido)propanoate and 2,4′-dichloro-[1,1′-biphenyl]-4-amine for ethyl 3-(5-(2-formyl-3-methoxy-5-(trifluoromethyl)phenyl)picolinamido)propanoate and 2-chloro-4′-(trifluoromethyl)-[1,1′-biphenyl]-4-amine, respectively.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e81bd1529b8c4835b54afce863db7d45
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748624B2
来源说明: uspto-grants-2014_06

反应 SMILES

[CH:1]([C:3]1[C:8]([OH:9])=[CH:7][C:6]([C:10]([F:13])([F:12])[F:11])=[CH:5][C:4]=1[C:14]1[CH:15]=[CH:16][C:17]([C:20]([NH:22][CH2:23][CH2:24][C:25]([O:27]CC)=[O:26])=[O:21])=[N:18][CH:19]=1)=O.[Cl:30][C:31]1[CH:36]=[C:35]([NH2:37])[CH:34]=[CH:33][C:32]=1[C:38]1[CH:43]=[CH:42][C:41]([Cl:44])=[CH:40][CH:39]=1.C(C1C(OC)=CC(C(F)(F)F)=CC=1C1C=CC(C(NCCC(OCC)=O)=O)=NC=1)=O.ClC1C=C(N)C=CC=1C1C=CC(C(F)(F)F)=CC=1>>[Cl:30][C:31]1[CH:36]=[C:35]([NH:37][CH2:1][C:3]2[C:8]([OH:9])=[CH:7][C:6]([C:10]([F:13])([F:12])[F:11])=[CH:5][C:4]=2[C:14]2[CH:15]=[CH:16][C:17]([C:20]([NH:22][CH2:23][CH2:24][C:25]([OH:27])=[O:26])=[O:21])=[N:18][CH:19]=2)[CH:34]=[CH:33][C:32]=1[C:38]1[CH:43]=[CH:42][C:41]([Cl:44])=[CH:40][CH:39]=1