HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4-(4-chlorophenyl)benzenamine → 3-(5-(2-(((2,4'-Dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-3-hydroxy-5-(trifluoromethyl)phenyl)picolinamido)propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4-(4-chlorophenyl)benzenamine | HCID 19878910 | — |
| Reactant | 2-Chloro-4'-(trifluoromethyl)-[1,1'-biphenyl]-4-amine | HCID 68834284 | — |
| Reactant | Ethyl 3-(5-(2-formyl-3-methoxy-5-(trifluoromethyl)phenyl)picolinamido)propanoate | HCID 86674280 | — |
| Reactant | Ethyl 3-(5-(2-formyl-3-hydroxy-5-(trifluoromethyl)phenyl)picolinamido)propanoate | HCID 86674288 | — |
| Product | 3-(5-(2-(((2,4'-Dichloro-[1,1'-biphenyl]-4-yl)amino)methyl)-3-hydroxy-5-(trifluoromethyl)phenyl)picolinamido)propanoic acid | HCID 71059918 | — |
Reaction Steps
The title compound was prepared as described in Example 159 substituting ethyl 3-(5-(2-formyl-3-hydroxy-5-(trifluoromethyl)phenyl)picolinamido)propanoate and 2,4′-dichloro-[1,1′-biphenyl]-4-amine for ethyl 3-(5-(2-formyl-3-methoxy-5-(trifluoromethyl)phenyl)picolinamido)propanoate and 2-chloro-4′-(trifluoromethyl)-[1,1′-biphenyl]-4-amine, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748624B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-e81bd1529b8c4835b54afce863db7d45 |
| Source note | uspto-grants-2014_06 |