HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(5-(2-formyl-3-(prop-1-en-2-yl)-5-(trifluoromethyl)phenyl)picolinamido)propanoate → Ethyl 3-(5-(2-(hydroxymethyl)-3-isopropyl-5-(trifluoromethyl)phenyl)picolinamido)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(5-(2-formyl-3-(prop-1-en-2-yl)-5-(trifluoromethyl)phenyl)picolinamido)propanoate | HCID 86674290 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl 3-(5-(2-(hydroxymethyl)-3-isopropyl-5-(trifluoromethyl)phenyl)picolinamido)propanoate | HCID 71059694 | — |
Reaction Steps
A solution of ethyl 3-(5-(2-formyl-3-(prop-1-en-2-yl)-5-(trifluoromethyl)phenyl)picolinamido)propanoate (150.1 mg, 0.35 mmol) in THF (5 mL) and MeOH (25 mL) was hydrogenated substituting H-Cube (10 Bar H2) at 40° C. at a flow rate of 1 mL/min. The resulting solution was concentrated to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748624B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-016e727f47f344399746509c69635178 |
| Source note | uspto-grants-2014_06 |