Hydrochloric Acid → HCID 43532698, compound

HRID 40546Notes

Reaction equation

HRID 40546 reaction equation
[O:1]=[S:2]1(=[O:17])[CH2:7][CH2:6][N:5]([CH:8]2[CH2:13][CH2:12][N:11](C(O)=O)[CH2:10][CH2:9]2)[CH2:4][CH2:3]1.Cl>ClCCl.O1CCOCC1>[NH:11]1[CH2:10][CH2:9][CH:8]([N:5]2[CH2:4][CH2:3][S:2](=[O:1])(=[O:17])[CH2:7][CH2:6]2)[CH2:13][CH2:12]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 676080954-(1,1-Dioxo-1lambda6-thiomorpholin-4-yl)-piperidine-1-carboxylic acid

Product 1

HCID 43532698HCID 43532698, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

0.786 g of tert-butyl ester of 4-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-piperidine-1-carboxylic acid is put in 5 ml of dichloromethane. 12.3 ml of 4M hydrochloric acid in dioxane is added at room temperature. The solution is stirred for 18 h and evaporated to dryness. The product thus obtained is returned to the basic state by means of tetraalkylammonium carbonate resin at a rate of 2 g per mmol. 0.555 g of 4-piperidin-4-yl-thiomorpholine 1,1-dioxide is obtained.

Workup

  1. customevaporated to dryness
  2. customThe product thus obtained

Sources & evidence

ORD record
ord-9a6d4185f94349fdb3f966984385e18c
Source dataset
uspto-grants-2013_09
Patent number
US08530473B2

Reaction notes

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