HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1,1-Difluoro-6-azaspiro(2.5)octane hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,1-Difluoro-6-aza-spiro[2.5]octane-6-carboxylic acid | HCID 67607983 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1,1-Difluoro-6-azaspiro(2.5)octane hydrochloride | HCID 67608291 | — |
Reaction Steps
1.2 g of tert-butyl ester of 1,1-difluoro-6-aza-spiro[2.5]octane-6-carboxylic acid is put in 24 mL of dichloromethane. 24 mL of 4M hydrochloric acid in dioxane is added at room temperature. The solution is stirred for 4 h and is evaporated to dryness. 1 g of 1,1-difluoro-6-aza-spiro[2.5]octane hydrochloride is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08530473B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-afa3c5c465d949e0816334119236475a |
| Source note | uspto-grants-2013_09 |