Hydrochloric Acid → 1,1-Difluoro-6-azaspiro(2.5)octane hydrochloride

HRID 40547Notes

Reaction equation

HRID 40547 reaction equation
[F:1][C:2]1([F:13])[C:4]2([CH2:9][CH2:8][N:7](C(O)=O)[CH2:6][CH2:5]2)[CH2:3]1.[ClH:14]>ClCCl.O1CCOCC1>[ClH:14].[F:1][C:2]1([F:13])[C:4]2([CH2:9][CH2:8][NH:7][CH2:6][CH2:5]2)[CH2:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 676079831,1-Difluoro-6-aza-spiro[2.5]octane-6-carboxylic acid

Product 1

HCID 676082911,1-Difluoro-6-azaspiro(2.5)octane hydrochloride

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

1.2 g of tert-butyl ester of 1,1-difluoro-6-aza-spiro[2.5]octane-6-carboxylic acid is put in 24 mL of dichloromethane. 24 mL of 4M hydrochloric acid in dioxane is added at room temperature. The solution is stirred for 4 h and is evaporated to dryness. 1 g of 1,1-difluoro-6-aza-spiro[2.5]octane hydrochloride is obtained.

Workup

  1. customis evaporated to dryness

Sources & evidence

ORD record
ord-afa3c5c465d949e0816334119236475a
Source dataset
uspto-grants-2013_09
Patent number
US08530473B2

Reaction notes

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