HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40558Generated: October 25, 2026
Acetic Anhydride → N-((1S)-1-(4-Bromophenyl)ethyl)acetamide
https://huagongshe.com/reaction/40558
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | (alphaS)-4-Bromo-alpha-methylbenzenemethanamine | HCID 852999 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-((1S)-1-(4-Bromophenyl)ethyl)acetamide | HCID 793484 | — |
Reaction Steps
To 200 g (1.00 mol) (S)-1-(4-bromophenyl)ethylamine in 800 mL DCM are slowly added 94.5 mL (1.00 mol) acetic anhydride while cooling the mixture to 20-30° C. Then the cooling is removed and the reaction mixture is stirred at r.t. over night. Afterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water. The org. layer is dried with MgSO4 and the solvent is removed in vacuo. The crude product is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08530460B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-79330a88ee4444a18d3c367b1401b50e |
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| Source note | uspto-grants-2013_09 |
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