反应详情

2.08 mL (26.0 mmol) Ethyliodide and 1.08 g (3.91 mmol) Ag2CO3 are added to a mixture of 500 mg (2.160 mmol) 4-bromo-5-fluoro-pyridin-2-ol in 10 mL DCM. The mixture is stirred at r.t. over night. Then the reaction mixture is quenched by the addition of water and DCM. After filtration the org. layer is separated, dried with Na2SO4 and the solvent is removed in vacuo.

1. customThen the reaction mixture is quenched by the addition of water and DCM
2. filtrationAfter filtration the org
3. customlayer is separated
4. dry with materialdried with Na2SO4
5. customthe solvent is removed in vacuo