反应详情

温度

160 °C

1.4 g (II) are placed in 10 ml dioxane, then 3.6 ml diisopropylethylamine and then 1 g of 1-aminocyclopropanemethanol (see 2.2) are added. The reaction mixture is heated to 160° C., until there is no further reaction, and cooled, then evaporated down. The residue is treated with cyclohexane/ethyl acetate (4:1) in the ultrasound bath, the solid is suction filtered and dried. 1.24 g (III-2) are obtained as a solid. Analytical HPLC-MS (method A): RT=1.01 min.

1. customno further reaction
2. temperaturecooled
3. customevaporated down
4. additionThe residue is treated with cyclohexane/ethyl acetate (4:1) in the ultrasound bath
5. filtrationfiltered
6. customdried
7. custom1.24 g (III-2) are obtained as a solid