反应详情

温度

120 °C

1.4 g 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine (II) are placed in 9 ml dioxane, then first 3.5 ml diisopropylethylamine, then 0.9 g D-norvalinol are added. The reaction mixture is heated in the microwave at 120° C., until there is no further reaction, and cooled, then evaporated down. The residue is treated with petroleum ether/ethyl acetate 9:1 in the ultrasound bath, the solid is suction filtered and dried. 1.5 g (III-3) are obtained as a solid.

1. customno further reaction
2. temperaturecooled
3. customevaporated down
4. additionThe residue is treated with petroleum ether/ethyl acetate 9:1 in the ultrasound bath
5. filtrationfiltered
6. customdried
7. custom1.5 g (III-3) are obtained as a solid