反应详情

温度

80 °C

0.533 g (II), 0.850 g (R)-1-amino-1-(4-fluorophenyl)-2-methylpropan-2-ol and 1.3 ml diisopropylethylamine are suspended in 9.8 ml dioxane. The reaction mixture is heated to 80° C. in the microwave for 2 hours and then evaporated to dryness. The residue is mixed with water. The precipitate formed is suction filtered and purified by chromatography (silica gel, petroleum ether/ethyl acetate 100/0 to 60/40). 0.260 g (III-4) are obtained as a solid. Analytical HPLC-MS (method A): 1.39 min.

1. customevaporated to dryness
2. additionThe residue is mixed with water
3. customThe precipitate formed
4. filtrationfiltered
5. custompurified by chromatography (silica gel, petroleum ether/ethyl acetate 100/0 to 60/40)
6. custom0.260 g (III-4) are obtained as a solid
7. custom1.39 min.