Trifluoroacetic acid → HCID 58117630, compound

HRID 405919Notes

Reaction equation

HRID 405919 reaction equation
[CH2:1]([N:3]([CH2:27][CH3:28])[CH2:4][CH2:5][O:6][C:7]1[CH:26]=[CH:25][C:10]([O:11][CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)=[CH:9][CH:8]=1)[CH3:2].FC(F)(F)C(O)=O>ClCCl>[CH2:27]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][O:6][C:7]1[CH:26]=[CH:25][C:10]([O:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[CH:9][CH:8]=1)[CH3:28]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58117574HCID 58117574, compound

Product 1

HCID 58117630HCID 58117630, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

10.1 g tert-butyl 4-[4-(2-diethylaminoethoxy)-phenoxy]-piperidine-1-carboxylate are placed in 20 ml dichloromethane and combined with 30 ml trifluoroacetic acid while being cooled. The reaction mixture is stirred at ambient temperature. After 2 hours the reaction mixture is evaporated to dryness. The residue is combined with an NaOH solution (1M) and the product is extracted with dichloromethane. 5.6 g (V-3) are obtained.

Workup

  1. temperaturewhile being cooled
  2. customAfter 2 hours the reaction mixture is evaporated to dryness
  3. extractionthe product is extracted with dichloromethane
  4. custom5.6 g (V-3) are obtained

Sources & evidence

ORD record
ord-bc1e7f0860d74f5dacf97451b493e409
Source dataset
uspto-grants-2014_06
Patent number
US08754073B2

Reaction notes

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