2-Amino-5-chlorophenol → HCID 58117890, compound

HRID 405923Notes

Reaction equation

HRID 405923 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[OH:9].[N:10]1(C(OC(C)(C)C)=O)[CH2:15][CH2:14][CH:13]([C:16]([O-])=O)[CH2:12][CH2:11]1>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]2[N:1]=[C:16]([CH:13]3[CH2:14][CH2:15][NH:10][CH2:11][CH2:12]3)[O:9][C:3]=2[CH:4]=1

Participants

3

Reactant 2

HCID 915912-Amino-5-chlorophenolHCID 6921829HCID 6921829, compound

Product 1

HCID 58117890HCID 58117890, compoundYield 103.1%

Procedure

500 mg 2-amino-5-chlorophenol and 800 mg mono-tert-butyl piperidine-1,4-dicarboxylate are heated to 200° C. in 4 ml polyphosphoric acid for 4 h. After cooling the reaction mixture is combined with ice water and stirred for 30 min. The precipitate is suction filtered, washed with water and dried. 850 mg product are obtained as the phosphate.

Workup

  1. temperatureAfter cooling the reaction mixture
  2. filtrationfiltered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-bfc808555a5742d8a71cbeab465bfb8f
Source dataset
uspto-grants-2014_06
Patent number
US08754073B2

Reaction notes

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