HCID 58117567, compound → (S)-5-amino-1-propylpiperidin-2-one

HRID 405927Notes

Reaction equation

HRID 405927 reaction equation
C([N:8](CC1C=CC=CC=1)[C@@H:9]1[CH2:14][N:13]([CH2:15][CH2:16][CH3:17])[C:12](=[O:18])[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[NH2:8][C@@H:9]1[CH2:14][N:13]([CH2:15][CH2:16][CH3:17])[C:12](=[O:18])[CH2:11][CH2:10]1

Participants

4

Reactant 1

HCID 58117567HCID 58117567, compound

Product 1

HCID 58117851(S)-5-amino-1-propylpiperidin-2-oneYield 82.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

0.569 g (S)-5-dibenzylamino-1-propylpiperidin-2-one are placed in 25 ml of methanol and hydrogenated with 0.150 g Pd/C 10% at a pressure of 3 bar and a temperature of 60° C. After 19 hours the catalyst is suction filtered and the filtrate is evaporated to dryness. 0.217 g of the product are obtained as an oil.

Workup

  1. customa temperature of 60° C
  2. filtrationsuction filtered
  3. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-e8b0e500918d4f5398e2f5c1f4dd1bf2
Source dataset
uspto-grants-2014_06
Patent number
US08754073B2

Reaction notes

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