HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → N-[(1-t-Butoxycarbonyl-4-phenylpiperidin-4-yl)methyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Tert-butyl 4-(aminomethyl)-4-phenylpiperidine-1-carboxylate | HCID 10565452 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[(1-t-Butoxycarbonyl-4-phenylpiperidin-4-yl)methyl]acetamide | HCID 58117727 | — |
Reaction Steps
8 g tert-butyl 4-aminomethyl-4-phenylpiperidine-1-carboxylate and 2.9 ml acetic anhydride are stirred in 80 ml of ethanol overnight at ambient temperature and then evaporated to dryness. 10.4 g product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08754073B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-4966f4e4a22049059dd86bdeab746d4e |
| Source note | uspto-grants-2014_06 |