Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Fluorobenzyl bromide | HCID 68021 | — |
| Reactant | (S)-5-dibenzylaminopiperidin-2-one | HCID 10780155 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58117917 | HCID 58117917 | — |
Reaction Steps
0.8 g (S)-5-dibenzylaminopiperidin-2-one (see 5.1) are placed in 8 ml dimethylformamide, then 200 mg sodium hydride (60% in mineral oil) and 0.4 ml 4-fluorobenzylbromide are added. The reaction mixture is stirred overnight at 70° C. and then combined with ice water. The precipitate is filtered off and washed with water. The product is purified by chromatography (silica gel, petroleum ether/ethyl acetate and ethyl acetate/methanol). 0.5 g product are obtained as an oil. Analytical HPLC-MS (method A): RT=1.21 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08754073B2 |
|---|
| Source dataset | uspto-grants-2014_06 |
|---|
| ORD ID | ord-f8d79e01c67a407a9c405e6ef2390a00 |
|---|
| Source note | uspto-grants-2014_06 |
|---|
