反应详情

温度

70 °C

0.8 g (S)-5-dibenzylaminopiperidin-2-one (see 5.1) are placed in 8 ml dimethylformamide, then 200 mg sodium hydride (60% in mineral oil) and 0.4 ml 4-fluorobenzylbromide are added. The reaction mixture is stirred overnight at 70° C. and then combined with ice water. The precipitate is filtered off and washed with water. The product is purified by chromatography (silica gel, petroleum ether/ethyl acetate and ethyl acetate/methanol). 0.5 g product are obtained as an oil. Analytical HPLC-MS (method A): RT=1.21 min.

1. filtrationThe precipitate is filtered off
2. washwashed with water
3. customThe product is purified by chromatography (silica gel, petroleum ether/ethyl acetate and ethyl acetate/methanol)