HCID 58117917, compound → HCID 58117573, compound

HRID 405936Notes

Reaction equation

HRID 405936 reaction equation
C([N:8](CC1C=CC=CC=1)[C@@H:9]1[CH2:14][N:13]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[C:12](=[O:23])[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[NH2:8][C@@H:9]1[CH2:14][N:13]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[C:12](=[O:23])[CH2:11][CH2:10]1

Participants

4

Reactant 1

HCID 58117917HCID 58117917, compound

Product 1

HCID 58117573HCID 58117573, compoundYield 76.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

0.5 g (S)-5-dibenzylamino-1-(4-fluorobenzyl)-piperidin-2-one are placed in 20 ml of methanol and hydrogenated with 0.150 g Pd/C 10% at a pressure of 3 bar and a temperature of 60° C. After 5 hours the catalyst is suction filtered and the filtrate is evaporated to dryness. 0.21 g of the product are obtained as an oil. Analytical HPLC-MS (method A): RT=0.68 min.

Workup

  1. customa temperature of 60° C
  2. filtrationsuction filtered
  3. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-8de7f9db1ec845e6942aa7f1c4bc4e00
Source dataset
uspto-grants-2014_06
Patent number
US08754073B2

Reaction notes

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