HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 58117917, compound → HCID 58117573, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 58117917 | HCID 58117917 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 58117573 | HCID 58117573 | 76.1% |
Reaction Steps
0.5 g (S)-5-dibenzylamino-1-(4-fluorobenzyl)-piperidin-2-one are placed in 20 ml of methanol and hydrogenated with 0.150 g Pd/C 10% at a pressure of 3 bar and a temperature of 60° C. After 5 hours the catalyst is suction filtered and the filtrate is evaporated to dryness. 0.21 g of the product are obtained as an oil. Analytical HPLC-MS (method A): RT=0.68 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08754073B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-8de7f9db1ec845e6942aa7f1c4bc4e00 |
| Source note | uspto-grants-2014_06 |